We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar and both common carotid arteries. The rats' brains were frozen in situ after 0, 5, or 30 minutes of ischemia or 10, 30, or 60 minutes of recirculation following 30 minutes of ischemia (n=5 at each time). Nucleoside triphosphate levels were higher in the phenytoin-treated rats than in corresponding untreated rats at each time during and after ischemia. Phenytoin significantly attenuated the accumulation of lactate and free fatty acids (arachidonic acid and stearic acid) during ischemia and accelerated their recovery during recirculation. These results suggest that phenytoin has favorable protective effects on ischemic brain and that phenytoin may inhibit calcium-mediated phenomena, especially the inositol cycle, in cerebral ischemia.
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UNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPANUNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN
GOTOH, O
KOIDE, T
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UNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPANUNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN
KOIDE, T
TAKAKURA, K
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UNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPANUNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN
机构:
UNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPANUNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN
GOTOH, O
KOIDE, T
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h-index: 0
机构:
UNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPANUNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN
KOIDE, T
TAKAKURA, K
论文数: 0引用数: 0
h-index: 0
机构:
UNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPANUNIV TOKYO, FAC MED, DEPT NEUROSURG, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN