ANTIASTHMATIC EFFECTS OF PICRORHIZA-KURROA - ANDROSIN PREVENTS ALLERGEN- AND PAF-INDUCED BRONCHIAL OBSTRUCTION IN GUINEA-PIGS

被引：55

作者：

DORSCH, W

STUPPNER, H

WAGNER, H

GROPP, M

DEMOULIN, S

RING, J

机构：

[1] UNIV MUNICH, INST PHARMACEUT BIOL, W-8000 MUNICH 2, GERMANY

[2] UNIV HAMBURG, KRANKENHAUS EPPENDORF, DEPT DERMATOL, W-2000 HAMBURG 20, GERMANY

[3] UNIV INNSBRUCK, INST PHARMACOGNOSY, A-6020 INNSBRUCK, AUSTRIA

[4] UNIV MUNICH, CHILDRENS HOSP, W-8000 MUNICH 2, GERMANY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 95卷 / 2-3期

关键词：

D O I：

10.1159/000235416

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In the Ayurvedic medicine, Picrorhiza kurroa Royle ex Benth. is used for the treatment of liver and lung diseases. Using different chemical and pharmacological methods, we could identify the phenol glycoside androsin as active compound preventing allergen and platelet-activating factor induced bronchial obstruction in guinea pigs in vivo (10 mg/kg p.o.; 1 h prior to the inhalation challenge). Histamine release from human polymorphonuclear leukocytes in vitro was inhibited by other compounds yet to be identified.

引用

页码：128 / 133

页数：6

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