PHOTOCHEMISTRY OF TIAPROFENIC ACID, A NONSTEROIDAL ANTIINFLAMMATORY DRUG WITH PHOTOTOXIC SIDE-EFFECTS

被引：16

作者：

BOSCA, F

MIRANDA, MA

VARGAS, F

机构：

[1] UNIV POLITECN VALENCIA, CSIC, DEPT QUIM, CAMINO VERA S-N, APARTADO 22012, E-46071 VALENCIA, SPAIN

[2] UNIV POLITECN VALENCIA, INST TECHNOL QUIM, E-46071 VALENCIA, SPAIN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1992年 / 81卷 / 02期

关键词：

D O I：

10.1002/jps.2600810215

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The phototoxic nonsteroidal anti-inflammatory drug tiaprofenic acid (1) is photolabile under aerobic conditions. Irradiation of a methanol solution of 1 under oxygen produces the photoproducts 2, 3, 4, and 5, and also produces a singlet oxygen as evidenced by trapping with 2,5-dimethylfuran.

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页码：181 / 182

页数：2

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