LPS STIMULATED INVERTEBRATE HEMOCYTES - A ROLE FOR IMMUNOREACTIVE TNF AND IL-1

被引：58

作者：

HUGHES, TK

SMITH, EM

BARNETT, JA

CHARLES, R

STEFANO, GB

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PSYCHIAT & BEHAV SCI,GALVESTON,TX 77550

[2] SUNY COLL OLD WESTBURY,DEPT BIOL SCI,OLD WESTBURY,NY 11568

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 1991年 / 15卷 / 03期

关键词：

INVERTEBRATES; TUMOR NECROSIS FACTOR; INTERLEUKIN-1; LIPOPOLYSACCHARIDE; MYTILUS-EDULIS;

D O I：

10.1016/0145-305X(91)90002-G

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Mytilus edulis hemocytes have similarities with vertebrate monocyte/macrophages. We have recently shown that they respond to human TNF and IL-1. We tested the possibility that Mytilus hemocytes produce similar substances in response to LPS. We show that Mytilus hemocytes respond to LPS in a fashion similar to vertebrate monocytes and macrophages and that these responses are inhibited by antibodies to TNF and/or IL-1. These findings are demonstrated both in vitro and in vivo.

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页码：117 / 122

页数：6

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