URINARY FLOW-RATES IN PATIENTS WITH BENIGN PROSTATIC HYPERTROPHY FOLLOWING TREATMENT WITH ALFUZOSIN

被引:58
作者
TEILLAC, P
DELAUCHECAVALLIER, MC
ATTALI, P
机构
[1] SYNTHELABO LERS,RECH,F-75621 PARIS 13,FRANCE
[2] HOP ST LOUIS,F-75010 PARIS,FRANCE
来源
BRITISH JOURNAL OF UROLOGY | 1992年 / 70卷 / 01期
关键词
D O I
10.1111/j.1464-410X.1992.tb15665.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
In order to document further the onset of action of alfuzosin, a selective alpha-1 blocker, 93 symptomatic patients with benign prostatic hypertrophy were randomly allocated to a single oral dose of either alfuzosin 1.25 mg or 2.5 mg, or placebo, after a 1-week placebo lead-in period. The effects on flow rates were assessed 1 h 30 min after administration. Peak and mean flow rates were significantly increased in the alfuzosin groups, as compared with placebo, in a dose-dependent manner. After a single intake of placebo, the mean values of these 2 parameters showed little change. The eff ect on the cardiovascular system (heart rate and blood pressure) was mild. This study indicates that the action of alfuzosin is already present 1 h 30 min after administration.
引用
收藏
页码:58 / 64
页数:7
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