MOLECULAR-BIOLOGY OF BOVINE HERPESVIRUS TYPE-4

被引:73
作者
THIRY, E [1 ]
BUBLOT, M [1 ]
DUBUISSON, J [1 ]
VANBRESSEM, MF [1 ]
LEQUARRE, AS [1 ]
LOMONTE, P [1 ]
VANDERPLASSCHEN, A [1 ]
PASTORET, PP [1 ]
机构
[1] STATE UNIV LIEGE, FAC VET MED, DEPT VIROL IMMUNOL, B-4000 LIEGE, BELGIUM
关键词
D O I
10.1016/0378-1135(92)90037-T
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bovine herpesvirus type 4 (BHV-4) is a ubiquitous virus of cattle. Its genome is a 144 +/- 6 kb double-stranded DNA consisting of a unique central part (L-DNA) flanked at both ends by tandem repeats called polyrepetitive DNA (prDNA or H-DNA). The overall arrangement of genes has been obtained by the analysis of homologies between short BHV-4 DNA sequences and corresponding genes of Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS). The gene expression is temporally regulated. Glycoprotein precursor p(gp10/gp17) is expressed as gamma 1 polypeptide. Glycoproteins gp 1, gp8, gp 11 and their precursors are gamma 2 proteins. The analysis of strain variations allows the definition of two types of strains, based on the DNA patterns: the Movar 33/63-like and the DN 599-like strains. Only the M40 strain, isolated in India, fails to fit this classification. The genomic variations have been compiled to build a dendrogram showing three levels of divergence between BHV-4 strains or isolates. The available molecular data indicate that the BHV-4 genome shares much similarity with the DNA of EBV and HVS, two representative members of the gammaherpesvirinae. BHV-4 may therefore be classified in the subfamily gammaherpesvirinae.
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页码:79 / 92
页数:14
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