EXCLUSION OF LINKAGE BETWEEN HYPOKALEMIC PERIODIC PARALYSIS (HOKPP) AND 3 CANDIDATE LOCI

被引：13

作者：

CASLEY, WL

ALLON, M

COUSIN, HK

TING, SS

CRACKOWER, MA

HASHIMOTO, L

CORNELIS, F

BECKMANN, JS

HUDSON, AJ

EBERS, GC

机构：

[1] UNIV WESTERN ONTARIO,UNIV HOSP,DEPT CLIN NEUROL SCI,LONDON N6A 5A5,ONTARIO,CANADA

[2] UNIV ALABAMA,CTR NEPHROL RES & TRAINING,DEPT MED,BIRMINGHAM,AL 35294

[3] INST MOLEC MED,OXFORD,ENGLAND

[4] CTR ETUD POLYMORPHISME HUMAIN,PARIS,FRANCE

来源：

GENOMICS | 1992年 / 14卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0888-7543(05)80249-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hypokalemic periodic paralysis (HOKPP) is an autosomal dominant neuromuscular disorder characterized by flaccid paralysis accompanied by lowered serum potassium levels. We have tested polymorphic markers linked to the adult skeletal muscle sodium channel (SCN4A) locus at 17q23-q25, the T-cell receptor β (TCRB) locus at 7q35, and the H-Ras cellular protooncogene locus (HRAS) at 11p15.5 for linkage with the affected phenotype in a single multigenerational pedigree. No evidence for genetic linkage to HOKPP was found at any of the candidate loci. © 1992 Academic Press, Inc. All rights reserved.

引用

页码：493 / 494

页数：2

共 13 条

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