LEWY BODIES IN THE LATERAL HYPOTHALAMUS - DO THEY IMPLY NEURONAL LOSS

被引:34
作者
KREMER, HPH
BOTS, GTAM
机构
[1] LEIDEN UNIV, ACAD HOSP DEPT NEUROL, 2300 RA LEIDEN, NETHERLANDS
[2] LEIDEN UNIV, ACAD HOSP, DEPT PATHOL, 2300 RA LEIDEN, NETHERLANDS
关键词
PARKINSONS DISEASE; LEWY BODY; HYPOTHALAMUS; LATERAL TUBERAL NUCLEUS; TUBEROMAMMILLARY NUCLEUS;
D O I
10.1002/mds.870080310
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Lewy bodies have been found in the hypothalamic lateral tuberal nucleus (NTL) and the adjoining tuberomammillary nucleus (TM) in Parkinson's disease (PD). The NTL is severely atrophic in Huntington's disease; the TM seems unaffected. In this study, we examined the NTL and the TM of seven PD patients and one patient with presumed PD to assess whether the presence of Lewy bodies indicated neuronal loss. Most Lewy bodies were found in the TM, but they were also present in the NTL of seven of the eight patients. The number of NTL neurons in the PD patients was similar to a group of 14 nonneurological controls, seven Alzheimer's disease (AD) patients, and two AIDS patients with dementia. This challenges the hypothesis that Lewy bodies are a sign of significant cell death. The TM, whose cells could not be counted, did not seem depleted in neuronal numbers, although occasional neuronophagia was observed.
引用
收藏
页码:315 / 320
页数:6
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