EFFECTS OF ANNEXIN-V ON THE ACTIVITY OF THE ANTICOAGULANT PROTEIN-C AND PROTEIN-S

被引：9

作者：

SUN, J

BIRD, P

SALEM, HH

机构：

[1] Department of Medicine, Monash Medical School, Clive Ward Centre, Box Hill

来源：

THROMBOSIS RESEARCH | 1993年 / 69卷 / 03期

基金：

英国医学研究理事会;

关键词：

ANTICOAGULANTS; ANNEXIN-V; PROTEIN-C; PROTEIN-S;

D O I：

10.1016/0049-3848(93)90025-J

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

引用

页码：279 / 287

页数：9

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