TRANSFORMATION OF 7-(4-HYDROXYPHENYLACETAMIDO)CEPHALOSPORANIC ACID INTO A NEW CEPHALOSPORIN ANTIBIOTIC, 7-[1-OXASPIRO(2.5)OCTA-6-OXO-4,7-DIENE-2-CARBOXAMIDO]CEPHALOSPORANIC ACID, BY LACCASE

被引：28

作者：

AGEMATU, H ^{[1
]}

KOMINATO, K ^{[1
]}

SHIBAMOTO, N ^{[1
]}

YOSHIOKA, T ^{[1
]}

NISHIDA, H ^{[1
]}

OKAMOTO, R ^{[1
]}

SHIN, T ^{[1
]}

MURAO, S ^{[1
]}

机构：

[1] KUMAMOTO INST TECHNOL, DEPT APPL MICROBIAL TECHNOL, IKEDA, KUMAMOTO 860, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 08期

关键词：

D O I：

10.1271/bbb.57.1387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

7-(4-Hydroxyphenvlacetamido)cephalosporanic acid (1) was transformed into 7-[1-oxaspiro(2.5)octa-6-oxo-4,7-diene-2-carboxamido]cephalosporanic acid (2) by laccase-catalyzed phenolic oxidation. 2 consisted of two diastereomers, named CXL-1 and CXL-2. CXL-2 was 10-30 times more active than CXL-1, although less active than 1.

引用

页码：1387 / 1388

页数：2

共 14 条

[1] ENZYMATIC DIMERIZATION OF PENICILLIN-X
AGEMATU, H
TSUCHIDA, T
KOMINATO, K
SHIBAMOTO, N
YOSHIOKA, T
NISHIDA, H
OKAMOTO, R
SHIN, T
MURAO, S
[J]. JOURNAL OF ANTIBIOTICS, 1993, 46 (01) : 141 - 148
[2] CORIOLUS-VERSICOLOR LACCASE CATALYZES THE DECARBOXYLATION OF 2-(4-HYDROXYPHENYL)-GLYCINE AND 4-HYDROXYMANDELIC ACID
AGEMATU, H
SHIBAMOTO, N
NISHIDA, H
OKAMOTO, R
SHIN, T
MURAO, S
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1992, 56 (07) : 1176 - 1177
[3] VANILLIC ACID METABOLISM BY THE WHITE-ROT FUNGUS SPOROTRICHUM-PULVERULENTUM
ANDER, P
HATAKKA, A
ERIKSSON, KE
[J]. ARCHIVES OF MICROBIOLOGY, 1980, 125 (03) : 189 - 202
[4] SEMISYNTHETIC BETA-LACTAM ANTIBIOTICS .2. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-BETA-[2-(ACYLAMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETAMIDO]CEPHALOSPORINS
ARIMOTO, M
EJIMA, A
WATANABE, T
TAGAWA, H
FURUKAWA, M
[J]. JOURNAL OF ANTIBIOTICS, 1986, 39 (09) : 1236 - 1242
[5] ASYMMETRIC DIPHENOL FORMATION BY A FUNGAL LACCASE
BOLLAG, JM
LIU, SY
MINARD, RD
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1979, 38 (01) : 90 - 92
[6] ENZYMATIC OLIGOMERIZATION OF VANILLIC ACID
BOLLAG, JM
LIU, SY
MINARD, RD
[J]. SOIL BIOLOGY & BIOCHEMISTRY, 1982, 14 (02) : 157 - 163
[7] COPOLYMERIZATION OF HALOGENATED PHENOLS AND SYRINGIC ACID
BOLLAG, JM
LIU, SY
[J]. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1985, 23 (02) : 261 - 272
[8] LARGE SCALE PRODUCTION AND PURIFICATION OF LACCASE FROM CULTURES OF FUNGUS POLYPORUS VERSICOLOR AND SOME PROPERTIES OF LACCASE A
FAHRAEUS, G
REINHAMMAR, B
[J]. ACTA CHEMICA SCANDINAVICA, 1967, 21 (09): : 2367 - +
[9] KAMETANI T, 1970, PHENOLIC OXIDATION
[10] KAWAI S, 1987, MOKUZAI GAKKAISHI, V33, P792

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