GENE FOR FAMILIAL PSORIASIS SUSCEPTIBILITY MAPPED TO THE DISTAL END OF HUMAN-CHROMOSOME 17Q

被引：315

作者：

TOMFOHRDE, J

SILVERMAN, A

BARNES, R

FERNANDEZVINA, MA

YOUNG, M

LORY, D

MORRIS, L

WUEPPER, KD

STASTNY, P

MENTER, A

BOWCOCK, A

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT PEDIAT, DALLAS, TX 75235 USA

[2] BAYLOR UNIV, MED CTR, CTR PSORIASIS, DALLAS, TX 75246 USA

[3] UNIV TEXAS, SW MED CTR, DEPT INTERNAL MED, DALLAS, TX 75235 USA

[4] OREGON HLTH SCI UNIV, DEPT DERMATOL, PORTLAND, OR 97201 USA

来源：

SCIENCE | 1994年 / 264卷 / 5162期

关键词：

D O I：

10.1126/science.8178173

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.

引用

页码：1141 / 1145

页数：5

共 40 条

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