CUSHINGS-SYNDROME FROM AN INHALED GLUCOCORTICOID

被引：13

作者：

CHALKLEY, SM ^{[1
]}

CHISHOLM, DJ ^{[1
]}

机构：

[1] GARVAN INST MED RES,DIV METAB,DARLINGHURST,NSW 2010,AUSTRALIA

来源：

MEDICAL JOURNAL OF AUSTRALIA | 1994年 / 160卷 / 10期

关键词：

D O I：

10.5694/j.1326-5377.1994.tb125866.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To report a case of significant systemic side effects from an inhaled glucocorticoid at a reported dose in the upper recommended therapeutic range. Clinical features: A 25-year-old white man with asthma treated with inhaled glucocorticoid (beclomethasone 1500 mu g daily), and primary testicular failure with inadequate androgen replacement, was referred with back pain. He was found to have osteoporosis, clinical features of Cushing's syndrome and complete suppression of endogenous adrenocorticotrophic hormone adrenal function. Intervention and outcome: He was recommended to receive adequate androgen replacement and to use a spacer device with the inhaled beclomethasone, or to change to budesonide via a Turbuhaler (AB Astra, Sweden). Conclusions: Inhaled glucocorticoids should not be regarded as entirely safe, as serious systemic side effects may occur at doses at the upper level of the recommended therapeutic range.

引用

页码：611 / 615

页数：5

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