EFFECT OF POLY(I) POLY(C12U) (AMPLIGEN) ON ENTERIC VIRUS (ROTAVIRUS, POLIOVIRUS AND COXSACKIE B3 VIRUS) INFECTIONS

被引：4

作者：

KONISHI, K

MUKOYAMA, A

MULLER, WEG

YAMAZAKI, S

USHIJIMA, H

机构：

[1] INST PUBL HLTH,DEPT MICROBIOL,MINATO KU,TOKYO 108,JAPAN

[2] NATL INST HLTH,DEPT VIRAL DIS & VACCINE CONTROL,TOKYO 141,JAPAN

[3] NATL INST HLTH,DEPT VIROL 2,SHUNJUKU KU,TOKYO 141,JAPAN

[4] UNIV MAINZ,INST PHYSIOL CHEM,MAINZ,GERMANY

来源：

LETTERS IN APPLIED MICROBIOLOGY | 1994年 / 19卷 / 05期

关键词：

D O I：

10.1111/j.1472-765X.1994.tb00483.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effects of poly(I).poly(C12U) (Ampligen) on infections with enteric viruses (rotavirus, poliovirus and Coxsackie B3 virus) were studied in vitro. Ampligen exhibited antiviral activity against rotavirus, especially when treatment was performed prior to inoculation of the virus. It was partially effective against Coxsackie B3 virus, but not against poliovirus. It is suggested that the observed effects may be due to the production of interferon induced by Ampligen.

引用

页码：386 / 390

页数：5

共 13 条

[1] AUGMENTATION OF NATURAL IMMUNE DEFENSE-MECHANISMS AND THERAPEUTIC POTENTIAL OF A MISMATCHED DOUBLE-STRANDED POLYNUCLEOTIDE IN CUTANEOUS HERPES-SIMPLEX VIRUS TYPE-2 INFECTION [J].