SUSTAINED-ACTION TABLETS PREPARED BY EMPLOYING A SPRAY-DRYING TECHNIQUE FOR GRANULATION

被引:19
作者
KORNBLUM, SS
机构
[1] Pharmacy Research and Development Department, Sandoz Pharmaceuticals, Hanover, New Jersey
关键词
Dissolution rates; tablets—spray‐dried powder effect; Particle‐size determination—spray‐dried powder; Spray‐dried powder—sustained‐action matrix; Sustained‐action tablets—spray‐drying technique;
D O I
10.1002/jps.2600580130
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A spray‐drying technique has been investigated which provides a free‐flowing powder with decreased dissolution rate for the medicinal agent when compressed into tablets. The fine powder (10–150 μ) obtained by this process has proved to possess excellent drug distribution and when tableted offers good reproducibility of drug release for consecutive batches. The consistency of the drug‐release pattern is tabulated and the drug‐release phenomena discussed. The effect of aging on the release rate of the sustained‐action tablets has been investigated. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:125 / &
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