SUSTAINED-ACTION TABLETS PREPARED BY EMPLOYING A SPRAY-DRYING TECHNIQUE FOR GRANULATION

被引：19

作者：

KORNBLUM, SS

机构：

[1] Pharmacy Research and Development Department, Sandoz Pharmaceuticals, Hanover, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Dissolution rates; tablets—spray‐dried powder effect; Particle‐size determination—spray‐dried powder; Spray‐dried powder—sustained‐action matrix; Sustained‐action tablets—spray‐drying technique;

D O I：

10.1002/jps.2600580130

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A spray‐drying technique has been investigated which provides a free‐flowing powder with decreased dissolution rate for the medicinal agent when compressed into tablets. The fine powder (10–150 μ) obtained by this process has proved to possess excellent drug distribution and when tableted offers good reproducibility of drug release for consecutive batches. The consistency of the drug‐release pattern is tabulated and the drug‐release phenomena discussed. The effect of aging on the release rate of the sustained‐action tablets has been investigated. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：125 / &

共 5 条

[1]

GAUNT WE, 1964, Patent No. 3148124

[2]

NEWTON JM, 1966, MANUF CHEMIST, V37, P33

[3] SPRAY-DRYING OF TABLET GRANULATIONS I - PRELIMINARY REPORT [J].