PHENYTOIN - EEG EFFECTS AND PLASMA-LEVELS IN VOLUNTEERS

被引：34

作者：

FINK, M

IRWIN, P

SANNITA, W

PAPAKOSTAS, Y

GREEN, MA

机构：

[1] Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, Long Island Research Institute, Stony Brook, NY

[2] Department of Neurology, Cornell University Medical College, New York, NY

[3] Institute for Neurophysiopathology, Genoa

来源：

THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 01期

关键词：

EEG effects; Pharmacodynamics; Phenytoin; Plasma levels;

D O I：

10.1097/00007691-197901000-00010

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The EEG and behavioral effects of oral doses of phenytoin from 100 mg to 1 g in normal male volunteers were measured. The EEG exhibited decreases in power in the slow frequencies and increases in the fast frequencies, accompanied by an increase in mean frequency. These changes are similar to those seen with psychostimulants. They occurred at average plasma levels of 8 .mu.g/ml and above. The time course and the intensity of EEG effects parallel plasma levels. Drug-related EEG changes were bilaterally symmetric. EEG changes at plasma levels of 8-12 .mu.g/ml were not associated with behavioral toxic signs. Future psychiatric studies of phenytoin as a psychostimulant should include monitoring for plasma levels, with a minimum of 8 .mu.g/ml as a guide to clinical efficacy.

引用

页码：93 / 103

页数：11

共 39 条

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