LFA-3, CD44, AND CD45 - PHYSIOLOGICAL TRIGGERS OF HUMAN MONOCYTE TNF AND IL-1 RELEASE

被引：316

作者：

WEBB, DSA

SHIMIZU, Y

VANSEVENTER, GA

SHAW, S

GERRARD, TL

机构：

[1] US FDA, CTR BIOL EVALUAT & RES, DIV CYTOKINE BIOL, BETHESDA, MD 20892 USA

[2] NCI, EXPTL IMMUNOL BRANCH, BETHESDA, MD 20892 USA

来源：

SCIENCE | 1990年 / 249卷 / 4974期

关键词：

D O I：

10.1126/science.1697984

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The monocyte-derived cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are central regulators ofthe immune response, but the physiologic stimuli for their release remain lagely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-α and IL-1β release. In addition, TNF-α was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.

引用

页码：1295 / 1297

页数：3

共 38 条

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