INTERACTIONS OF PHENCYCLIDINE RECEPTOR AGONIST MK-801 WITH DOPAMINERGIC SYSTEM - REGIONAL STUDIES IN THE RAT

被引：127

作者：

RAO, TS ^{[1
]}

KIM, HS ^{[1
]}

LEHMANN, J ^{[1
]}

MARTIN, LL ^{[1
]}

WOOD, PL ^{[1
]}

机构：

[1] CIBA GEIGY CORP,DIV PHARMACEUT,RES DEPT,SUMMIT,NJ 07901

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 54卷 / 04期

关键词：

Dopamine metabolism; MK‐801; Phencyclidine;

D O I：

10.1111/j.1471-4159.1990.tb01943.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interactions of the potent phencyclidine receptor agonist MK‐801 with the dopaminergic system were examined in various brain regions in the rat. MK‐801 increased dopamine (DA) metabolism in the pyriform cortex, entorhinal cortex, prefrontal cortex, striatum, olfactory tubercle, amygdala, and septum without affecting DA metabolism in the cingulate cortex and nucleus accumbens. In pyriform cortex and amygdala, MK‐801 was more potent than phencyclidine at increasing DA metabolism. Local injections of MK‐801 into ventral tegmental area and into the amygdala/pyriform cortex interface indicated that MK‐801 may act at the cell body as well as the nerve terminal level to increase DA metabolism and that ongoing dopaminergic neuronal activity is a prerequisite for full drug action. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1157 / 1162

页数：6

共 33 条

[1]

BANNON MJ, 1983, PHARMACOL REV, V35, P53

[2]

BANNON MJ, 1983, EUR J PHARMACOL, V91, P119

[3] LSD - EFFECT ON MONOAMINE METABOLITES IN RAT PREFRONTAL CORTEX [J].

BOWERS, MB ;

SALOMONSSON, LA .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (24) :4093-4096

[4] DIFFERENTIAL CONTROL BY N-METHYL-D-ASPARTATE AND KAINATE OF STRIATAL DOPAMINE RELEASE INVIVO - A TRANS-STRIATAL DIALYSIS STUDY [J].

CARTER, CJ ;

LHEUREUX, R ;

SCATTON, B .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (02) :462-468

[5] CENTRAL SYMPATHOMIMETIC ACTIVITY OF (+)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO [A,D]CYCLOHEPTEN-5, 10-IMINE (MK-801), A SUBSTANCE WITH POTENT ANTICONVULSANT, CENTRAL SYMPATHOMIMETIC, AND APPARENT ANXIOLYTIC PROPERTIES [J].

CLINESCHMIDT, BV ;

MARTIN, GE ;

BUNTING, PR ;

PAPP, NL .

DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :135-145

[6] ANTICONVULSANT ACTIVITY OF (+)-5-METHYL-10, 11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5, 10-IMINE (MK-801), A SUBSTANCE WITH POTENT ANTICONVULSANT, CENTRAL SYMPATHOMIMETIC, AND APPARENT ANXIOLYTIC PROPERTIES [J].

CLINESCHMIDT, BV ;

MARTIN, GE ;

BUNTING, PR .

DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :123-134

[7] RESTORATION OF SHOCK-SUPPRESSED BEHAVIOR BY TREATMENT WITH (+)-5-METHYL-10, 11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5, 10-IMINE (MK-801), A SUBSTANCE WITH POTENT ANTICONVULSANT, CENTRAL SYMPATHOMIMETIC, AND APPARENT ANXIOLYTIC PROPERTIES [J].

CLINESCHMIDT, BV ;

WILLIAMS, M ;

WITOSLAWSKI, JJ ;

BUNTING, PR ;

RISLEY, EA ;

TOTARO, JA .

DRUG DEVELOPMENT RESEARCH, 1982, 2 (02) :147-163

[8] STEREOTYPED BEHAVIOR CORRELATES BETTER THAN ATAXIA WITH PHENCYCLIDINE-RECEPTOR INTERACTIONS [J].

CONTRERAS, PC ;

RICE, KC ;

JACOBSON, AE ;

ODONOHUE, TL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 121 (01) :9-18

[9] AUTORADIOGRAPHIC DISTRIBUTION OF PHENCYCLIDINE RECEPTORS IN THE RAT-BRAIN USING [3H]1-(1-(2-THIENYL)CYCLOHEXYL)PIPERIDINE([3H]TCP) [J].

CONTRERAS, PC ;

QUIRION, R ;

ODONOHUE, TL .

NEUROSCIENCE LETTERS, 1986, 67 (02) :101-106

[10] ACTH1-24 AND LYSINE VASOPRESSIN SELECTIVELY ACTIVATE DOPAMINE SYNTHESIS IN FRONTAL-CORTEX [J].

DELANOY, RL ;

KRAMARCY, NR ;

DUNN, AJ .

BRAIN RESEARCH, 1982, 231 (01) :117-129

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