A CELLULAR FACTOR BINDING TO THE TAATGARAT DNA-SEQUENCE PREVENTS THE EXPRESSION OF THE HSV IMMEDIATE-EARLY GENES FOLLOWING INFECTION OF NONPERMISSIVE CELL-LINES DERIVED FROM DORSAL-ROOT GANGLION NEURONS

被引：13

作者：

WHEATLEY, SC

DENT, CL

WOOD, JN

LATCHMAN, DS

机构：

[1] UNIV COLL & MIDDLESEX SCH MED, DEPT BIOCHEM,MED MOLEC BIOL UNIT,WINDEYER BLDG, CLEVELAND, LONDON W1P 6DB, ENGLAND

[2] SANDOZ INST MED RES, DEPT NEUROIMMUNOL, LONDON WC1E 6BN, ENGLAND

来源：

EXPERIMENTAL CELL RESEARCH | 1991年 / 194卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0014-4827(91)90132-E

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell lines derived from dorsal root ganglion neurons are nonpermissive for HSV infection and do not transcribe the viral immediate-early genes following infection. The lack of immediate-early gene transcription in these cells is caused by the presence of a neuronal cell specific inhibitory factor which binds to the TAATGARAT elements in the promoters of these genes and prevents their transcription. The significance of these results for an understanding of the processes regulating the interaction of HSV with neuronal cell types and the establishment of latent infections in vivo is discussed. © 1991.

引用

页码：78 / 82

页数：5

共 23 条

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