THE USE OF ALBUMIN MICROSPHERES IN THE TREATMENT OF CARRAGEENAN-INDUCED INFLAMMATION IN THE RAT

被引：10

作者：

LEWIS, DA

FIELD, WN

HAYES, K

ALPAR, HO

机构：

[1] Pharmaceutical Sciences Institute, Aston University, Birmingham

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb03600.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Free hydrocortisone, hydrocortisone incorporated into Microspheres and empty microspheres have been administered orally to rats with carrageenan-induced hindpaw inflammation. Hydrocortisone administered in particles was effective at a lower dose than free steroid in reducing inflammation. Inflammatory exudates were able to release steroid from the microspheres by proteolytic degradation.

引用

页码：271 / 274

页数：4

共 17 条

[1]

ALPAR H O, 1989, Journal of Pharmacy and Pharmacology, V41, p50P

[2] THE TRANSPORT OF MICROSPHERES FROM THE GASTROINTESTINAL-TRACT TO INFLAMMATORY AIR POUCHES IN THE RAT [J].