EFFICIENT PRODUCTION OF HUMAN-IMMUNODEFICIENCY-VIRUS PROTEINS IN TRANSGENIC MICE

被引:19
作者
JOLICOEUR, P [1 ]
LAPERRIERE, A [1 ]
BEAULIEU, N [1 ]
机构
[1] UNIV MONTREAL, DEPT MICROBIOL & IMMUNOL, MONTREAL H3C 3J7, QUEBEC, CANADA
关键词
D O I
10.1128/JVI.66.6.3904-3908.1992
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Transgenic mice containing the complete human immunodeficiency virus (HIV) coding sequences fused to the mouse mammary tumor virus long terminal repeat were generated. They were found to produce high levels of authentic gag and env HIV proteins in several tissues known to support mouse mammary tumor virus-driven transcription. HIV proteins were also detected in serum and in body fluids (milk and epididymal secretions) known to be natural sites of retrovirus, and specifically of HIV, production. These results indicate that primary mouse cells from different tissues have the capacity to produce HIV proteins. These mice represent a novel animal model for HIV infection.
引用
收藏
页码:3904 / 3908
页数:5
相关论文
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