DEMOGRAPHY OF GENOTYPES - FAILURE OF THE LIMITED LIFE-SPAN PARADIGM IN DROSOPHILA-MELANOGASTER

被引:306
作者
CURTSINGER, JW
FUKUI, HH
TOWNSEND, DR
VAUPEL, JW
机构
[1] ODENSE UNIV,SCH MED,DK-5230 ODENSE,DENMARK
[2] DUKE UNIV,CTR DEMOG STUDIES,DURHAM,NC 27706
关键词
D O I
10.1126/science.1411541
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Experimental systems that are amenable to genetic manipulation can be used to address fundamental questions about genetic and nongenetic determinants of longevity. Analysis of large cohorts of ten genotypes of Drosophila melanogaster raised under conditions that favored extended survival has revealed variation between genotypes in both the slope and location of age-specific mortality curves. More detailed examination of a single genotype showed that the mortality trajectory was best fit by a two-stage Gompertz model, with no age-specific increase in mortality rates beyond 30 days after emergence. These results are contrary to the limited life-span paradigm, which postulates well-defined, genotype-specific limits on life-span and brief periods of intense and rapidly accelerating mortality rates at the oldest ages.
引用
收藏
页码:461 / 463
页数:3
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