SIMULTANEOUS DETERMINATION OF (R)-NAPROXEN AND (S)-NAPROXEN AND (R)-6-O-DESMETHYLNAPROXEN AND (S)-6-O-DESMETHYLNAPROXEN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON A CHIRAL-AGP COLUMN

被引：28

作者：

ANDERSEN, JV ^{[1
]}

HANSEN, SH ^{[1
]}

机构：

[1] ROYAL DANISH SCH PHARM,PHARMABIOTEC RES CTR,DEPT ORGAN CHEM,2 UNIV SPARKEN,DK-2100 COPENHAGEN,DENMARK

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 577卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80260-W

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method for the simultaneous determination of both enantiomers of naproxen and its metabolite 6-O-desmethylnaproxen has been developed. The separation is performed on a column containing alpha-1-acid glycoprotein as the chiral selector. The method has been used for the determination of the enantiomeric purity of the drug substance and the metabolite, and for the simultaneous determination of all four compounds in biological fluids.

引用

页码：362 / 365

页数：4

共 11 条

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