INHALATION KINETICS OF C8 TO C10 1-ALKENES AND ISO-ALKANES IN THE RAT AFTER REPEATED EXPOSURES

被引：25

作者：

ZAHLSEN, K ^{[1
]}

EIDE, I ^{[1
]}

NILSEN, AM ^{[1
]}

NILSEN, OG ^{[1
]}

机构：

[1] STATOIL,RES CTR,N-7004 TRONDHEIM,NORWAY

来源：

PHARMACOLOGY & TOXICOLOGY | 1993年 / 73卷 / 03期

关键词：

D O I：

10.1111/j.1600-0773.1993.tb01557.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The toxicokinetic properties of C8 and C10 1-alkenes and iso-alkanes have been investigated in rats during inhalation of 100 p.p.m. of the single hydrocarbons for 3 days, 12 hr/day. The concentration of hydrocarbon was measured in blood, brain, liver, kidneys and perirenal fat at days 1, 2 and 3. immediately after exposure and 12 hr after exposure on day 3. The 1-alkenes showed an efficient absorption to blood combined with extensive accumulation in organs, compared to the iso-alkanes. The concentration of 1-alkenes and iso-alkanes in blood, brain, liver and fat increased with increasing number of carbon atoms. The C9 and C10 1-alkenes and iso-alkanes showed increasing concentration in fat during the exposure period and high concentrations 12 hr after cessation of exposure. The extensive accumulation in both blood and organs of 1-alkenes compared to any of the other groups of hydrocarbons may have a toxicologic relevance. Products which contain 1-alkenes should be handled carefully to minimize the risk of inhalation exposure.

引用

页码：163 / 168

页数：6

共 7 条

[1] THE CYTOCHROME-P450-I GENE FAMILY OF MICROSOMAL HEMOPROTEINS AND THEIR ROLE IN THE METABOLIC-ACTIVATION OF CHEMICALS [J].