EVIDENCE FOR THE IMPORTANCE OF IRON IN THE ALPHA-OXIDATION OF 3-METHYL-SUBSTITUTED FATTY-ACIDS IN THE INTACT CELL

被引:10
作者
CROES, K [1 ]
CASTEELS, M [1 ]
VANVELDHOVEN, PP [1 ]
MANNAERTS, GP [1 ]
机构
[1] KATHOLIEKE UNIV LEUVEN, AFDELING FARMACOL, B-3000 LOUVAIN, BELGIUM
来源
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1995年 / 1255卷 / 01期
关键词
ALPHA-OXIDATION; 3-METHYL-BRANCHED FATTY ACID; PHYTANIC ACID; PEROXISOME; REFSUM; IRON;
D O I
10.1016/0005-2760(94)00209-H
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Preincubation of isolated rat hepatocytes with desferrioxamine or o-phenanthroline, two iron-specific chelators, strongly suppressed the CO2-production from the alpha-oxidation of 3-methylmargaric acid, whereas the beta-oxidation of 2-methylpalmitic acid, palmitic acid, trihydroxycoprostanic acid and the conversion of formic acid to CO2 were not affected. When, after the initial preincubation with the chelators and prior to the addition of 3-methylmargaric acid, iron-saturated transferrin and Fe3+ were added, a partial restitution of the CO2-production rates was obtained. These facts provide further evidence for the importance of iron in the alpha-oxidation of 3-methyl-substituted fatty acids.
引用
收藏
页码:63 / 67
页数:5
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