DEXAMETHASONE INHIBITS ALPHA-FETOPROTEIN GENE-EXPRESSION IN DEVELOPING MOUSE-LIVER

被引：56

作者：

COMMER, P

SCHWARTZ, C

TRACY, S

TAMAOKI, T

CHIU, JF

机构：

[1] UNIV CALGARY,FAC MED,ONCOL RES GRP,CALGARY T2N 1N4,ALBERTA,CANADA

[2] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92037

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(79)92149-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of dexamethasone on α-fetoprotein gene expression was studied in newborn mice. The treatment of 3 day old mice with 1 μg/gm body weight of dexamethasone twice a day reduced the α-fetoprotein level in serum to about 2.5% of the normal control level after 4 days of administration. The level of α-fetoprotein mRNA sequences in the cytoplasm decreased to about 1% of the control over this same period. Furthermore, only an extremely low concentration of α-fetoprotein mRNA sequences in nuclear RNA could be detected even at a high Crot. These results suggest that dexamethasone inhibits transcription of the α-fetoprotein gene in newborn mice. © 1979.

引用

页码：1294 / 1299

页数：6