EFFECT OF ANGIOTENSIN-II ON INVITRO PROLACTIN AND LH-RELEASE FROM THE RAT PITUITARY

The effect of angiotensin II (A II) on prolactin (PRL) and LH release was investigated in vitro using the rat pituitary hypothalamus system. Angiotensin induced a rapid, although shortlasting, increase in PRL release followed by a second peak after a 90-min interval. The release of LH was suppressed throughout the entire experimental period. This effect of A II on PRL release was not obtainable with isolated pituitaries only. It is concluded that A II might stimulate PRL release and inhibit LH release from the pituitary gland through an indirect hypothalamic mechanism. © 1979.