SYNTHESIS OF 4-SUBSTITUTED PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDES

被引:14
作者
DENAPOLI, L
MESSERE, A
MONTESARCHIO, D
PICCIALLI, G
SANTACROCE, C [1 ]
机构
[1] UNIV NAPLES,DIPARTIMENTO CHIM ORGAN & BIOL,VIA MEZZOCANNONE 16,I-80134 NAPLES,ITALY
[2] CNR,IST BIOCHIM PROT & ENZIMOL,I-80100 NAPLES,ITALY
来源
NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 08期
关键词
D O I
10.1080/15257779108043057
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reaction of 5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-deoxythy-midine with triphenylphosphine/carbon tetrachloride, followed by deprotection of the 5'-hydroxyl group, afforded the 4-chloro derivative 3 from which some 4-substituted pyrimidin-2(1H)one-2',3'-dideoxyribosides were obtained by nucleophilic substitution under very mild conditions.
引用
收藏
页码:1719 / 1728
页数:10
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