STRUCTURE AND HEPATOPROTECTIVE ACTIVITY OF A BIFLAVONOID FROM CANARIUM-MANII

被引：26

作者：

ANAND, KK

GUPTA, VN

RANGARI, V

SINGH, B

CHANDAN, BK

机构：

[1] Department of Pharmacology, Regional Research Laboratory, Jammu-Tawi 180 001, Canal Road

来源：

PLANTA MEDICA | 1992年 / 58卷 / 06期

关键词：

CANARIUM-MANII; NUTSHELL; BIFLAVONOID; HEPATOPROTECTIVE ACTIVITY; CCL4-INDUCED HEPATOTOXICITY;

D O I：

10.1055/s-2006-961533

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Canarium manii (Burseraceae) was chemically investigated and the presence of the biflavonoid agathisflavone is reported for the first time from this plant. Pharmacologically, this biflavonoid in doses 50.0 mg and 100.0 mg given orally exhibited dose-dependent hepatoprotective activity against experimentally-induced carbon tetrachloride-hepatotoxicity in rats and mice.

引用

页码：493 / 495

页数：3

共 19 条

[1]

ANSARI FR, 1978, INDIAN J CHEM B, V16, P846

[2]

BRAUER RW, 1946, J PHARMACOL EXP THER, V88, P109

[3] C-13-NMR SPECTROSCOPY OF BIFLAVANOIDS [J].

CHARI, VM ;

ILYAS, M ;

WAGNER, H ;

NESZMELYI, A ;

CHEN, FC ;

CHEN, LK ;

LIN, YC ;

LIN, YM .

PHYTOCHEMISTRY, 1977, 16 (08) :1273-1278

[4]

CHAZAL KK, 1970, J CHROMATOGR, V48, P484

[5] SMALLER HALOGENATED ALIPHATIC HYDROCARBONS [J].

CHENOWETH, MB ;

HAKE, CL .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1962, 2 :363-+

[6] NEW TABLES FOR MULTIPLE COMPARISONS WITH CONTROL [J].

DUNNETT, CW .

BIOMETRICS, 1964, 20 (03) :482-&

[7]

FUJIMOTO JM, 1960, J PHARMACOL EXP THER, V129, P139

[8]

IWN MM, 1985, EXPERIENTIA, V41, P699

[9]

KING J, 1978, CLIN BIOCH PRINCIPLE, V2, P1148

[10]

KLAASSEN C D, 1968, Toxicology and Applied Pharmacology, V12, P132, DOI 10.1016/0041-008X(68)90182-8

← 1 2 →