DOWN-REGULATION OF THE ANGIOTENSIN-II RECEPTOR SUBTYPE AT(2) IN HUMAN MYOMETRIUM DURING PREGNANCY

被引：34

作者：

DEGASPARO, M

WHITEBREAD, S

KALENGA, MK

DEHERTOGH, R

CREVOISIER, P

THOMAS, K

机构：

[1] UNIV CATHOLIQUE LOUVAIN,FAC MED,PHYSIOL HUMAN REPROD UNIT,B-1200 BRUSSELS,BELGIUM

[2] HOP REG,DEPT OBSTET & GYNAECOL,CH-2800 DELEMONT,SWITZERLAND

来源：

REGULATORY PEPTIDES | 1994年 / 53卷 / 01期

关键词：

HUMAN; MYOMETRIUM; PREGNANCY; ANGIOTENSIN II; RECEPTOR; SUBTYPE;

D O I：

10.1016/0167-0115(94)90157-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Samples of human myometrium have been collected during pregnancy and from non-pregnant women. Binding studies revealed the presence of a 50-fold higher density of angiotensin II AT(2) receptor in the non-pregnant state than during gestation. Low levels of the AT(1) receptor subtype (approx. 20 fmol/mg protein) were detected in both pregnant and non-pregnant myometrium. Outside pregnancy, the AT(2) receptor accounted for greater than 95% of all angiotensin receptors, whereas during pregnancy the value dropped to about 40%. The down regulation of the human myometrial AT(2) receptor during pregnancy may be related to the high hormonal content of the environment induced by gestation. The mechanism by which the AT(2) receptor is regulated appears to be different to that of the AT(1) receptor.

引用

页码：39 / 45

页数：7

共 26 条

[1] THE ANGIOTENSIN-AT2 RECEPTOR STIMULATES PROTEIN TYROSINE PHOSPHATASE-ACTIVITY AND MEDIATES INHIBITION OF PARTICULATE GUANYLATE-CYCLASE [J].