A NOVEL ONE-STEP SYNTHESIS OF QUINOLINIUM SALTS AND 4-QUINOLONES FROM FORMANILIDES

被引：25

作者：

METHCOHN, O

TAYLOR, DL

机构：

[1] Chemistry Department, University of Sunderland, Sunderland

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)73654-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Methylformanilide in POCl3 reacts readily at 80-degrees-C with alkanoamides(RCH2CONR2) to give 3-R-4-chloroquinolinium salts in good yields. The arylamide reacts as its Vilsmeier salt and the alkanoamide as an alpha-chloroenamine. High yields of 4-quinolones are easily obtained by base treatment.

引用

页码：3629 / 3632

页数：4

共 5 条

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[2] VINYLFORMYLATION UTILIZING PROPENIMINIUM SALTS
LEE, GT
AMEDIO, JC
UNDERWOOD, R
PRASAD, K
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (11) : 3250 - 3252
[3] MERCHANT JR, 1979, CHEM IND-LONDON, V9, P320
[4] THE SYNTHESIS OF PYRIDINES, QUINOLINES AND OTHER RELATED SYSTEMS BY THE VILSMEIER AND THE REVERSE VILSMEIER METHOD
METHCOHN, O
[J]. HETEROCYCLES, 1993, 35 (01) : 539 - 557
[5] METHCOHN O, 1982, ADV HETEROCYCL CHEM, V31, P207

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