A MODEL FOR MAGNETIZATION-TRANSFER IN TISSUES

被引:252
作者
MORRISON, C
HENKELMAN, RM
机构
[1] SUNNYBROOK HLTH SCI CTR,TORONTO,ON M4N 3M5,CANADA
[2] UNIV TORONTO,DEPT MED BIOPHYS,TORONTO,ON,CANADA
[3] UNIV TORONTO,DEPT MED IMAGING,TORONTO,ON,CANADA
关键词
MAGNETIZATION TRANSFER; TISSUES; SUPERLORENTZIAN; MODEL;
D O I
10.1002/mrm.1910330404
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Magnetization transfer in several tissues is measured and successfully modeled using a two-pool model of exchange. The line shape for the semi-solid pool is characterized by a superLorentzian and the liquid pool by a Lorentzian. The tissues investigated were white and gray matter, optic nerve, muscle, and liver. All tissues the authors studied are characterized by the same model but differ in the parameter values of the model. Blood and cerebral spinal fluid (CSF) were also investigated. The two-pool model with a Lorentzian line shape for both the semi-solid and liquid pools modeled the magnetization transfer in blood. In CSF, as expected, there is no measurable exchange of magnetization. The T-2B, associated with the semi-solid pool was short (similar to 10 mu s) for all tissues indicating a fairly rigid semi-solid pool. In addition characterization of the line shape as superLorentzian indicates molecules such as integral membrane proteins or lipids in membranes are likely molecules participating in the exchange. Conversely, in blood large globular proteins are indicated due to the Lorentzian nature of the semi-solid pool and a T-2B approximate to 300 mu s.
引用
收藏
页码:475 / 482
页数:8
相关论文
共 33 条
[1]  
BAUDOUIN CJ, 1993, 12TH P SMRM ANN M, P862
[2]   COMPLETE PROTON MAGNETIC-RESONANCE IN WHOLE CELLS [J].
BLOOM, M ;
HOLMES, KT ;
MOUNTFORD, CE ;
WILLIAMS, PG .
JOURNAL OF MAGNETIC RESONANCE, 1986, 69 (01) :73-91
[3]   NUCLEAR MAGNETIC-RESONANCE LINE-SHAPES IN LYOTROPIC LIQUID-CRYSTALS AND RELATED SYSTEMS [J].
BLOOM, M ;
BURNELL, EE ;
ROEDER, SBW ;
VALIC, MI .
JOURNAL OF CHEMICAL PHYSICS, 1977, 66 (07) :3012-3020
[4]  
BOORSTEIN JM, 1994, NEURORADIOLOGY, V191, P799
[5]   DETERMINATION OF PROTON MAGNETIZATION-TRANSFER RATE CONSTANTS IN HETEROGENEOUS BIOLOGICAL-SYSTEMS [J].
BROOKS, D ;
KUWATA, K ;
SCHLEICH, T .
MAGNETIC RESONANCE IN MEDICINE, 1994, 31 (03) :331-336
[6]   INCORPORATION OF SATURATION TRANSFER INTO THE FORMALISM FOR ROTATING-FRAME SPIN-LATTICE NMR RELAXATION IN THE PRESENCE OF AN OFF-RESONANCE-IRRADIATION FIELD [J].
CAINES, GH ;
SCHLEICH, T .
JOURNAL OF MAGNETIC RESONANCE, 1991, 95 (03) :457-476
[7]   INCORPORATION OF MAGNETIZATION TRANSFER INTO THE FORMALISM FOR ROTATING-FRAME SPIN-LATTICE PROTON NMR RELAXATION IN THE PRESENCE OF AN OFF-RESONANCE-IRRADIATION FIELD [J].
CAINES, GH ;
SCHLEICH, T ;
RYDZEWSKI, JM .
JOURNAL OF MAGNETIC RESONANCE, 1991, 95 (03) :558-566
[8]   PULSED NMR IN DYNAMICALLY HETEROGENEOUS SYSTEMS [J].
CHARVOLIN, J ;
RIGNY, P .
JOURNAL OF MAGNETIC RESONANCE, 1971, 4 (01) :40-+
[9]  
DESOUZA NM, 12TH P SMRM ANN M, P184
[10]   QUANTITATIVE H-1 MAGNETIZATION TRANSFER IMAGING INVIVO [J].
ENG, J ;
CECKLER, TL ;
BALABAN, RS .
MAGNETIC RESONANCE IN MEDICINE, 1991, 17 (02) :304-314