CYTOPLASMIC C-ERBB-2 PROTEIN EXPRESSION CORRELATES WITH SURVIVAL IN DUKES B-COLORECTAL CARCINOMA

被引：47

作者：

KAY, EW ^{[1
]}

MULCAHY, H ^{[1
]}

WALSH, CB ^{[1
]}

LEADER, M ^{[1
]}

ODONOGHUE, D ^{[1
]}

机构：

[1] ST VINCENTS HOSP,GASTROENTEROL & LIVER UNIT,DUBLIN,IRELAND

来源：

HISTOPATHOLOGY | 1994年 / 25卷 / 05期

关键词：

C-ERBB-2; COLORECTAL CARCINOMA; PROGNOSIS;

D O I：

10.1111/j.1365-2559.1994.tb00007.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The prognostic significance of c-erbB-2 expression was studied in paraffin wax embedded colorectal cancer tissue using a monoclonal antibody. One hundred and sixty-four patients with Dukes' B disease were studied. Membranous staining was not detected in any case. Cytoplasmic c-erbB-2 staining was seen in 55 cancers (33.5%). Cytoplasmic staining was unrelated to patient age (P = 0.31), sex (P = 0.69), tumour site (P = 0.69), size (P = 0.57), histological grade (P = 0.42) or ploidy status (P = 0.21) but was found more frequently in obstructing cancers (P = 0.03). Mean follow up of the patient population was 6.3 years. Five-year-survival estimated by the Kaplan-Meier life-table method was 47% for those with cytoplasmic c-erbB-2 staining and 77% for those without (log rank analysis; P less than or equal to 0.0001). Stepwise regression analysis identified c-erbB-2 staining (relative risk, 2.51; P = 0.0005) and bowel obstruction (relative risk, 1.99; P = 0.015) as independent predictors of survival. It is suggested that cytoplasmic c-erbB-2 expression may provide a useful marker of tumour behaviour in Dukes' B colorectal cancer.

引用

页码：455 / 461

页数：7

共 35 条

[1] THE PROGNOSTIC SIGNIFICANCE OF DIRECT EXTENSION OF CARCINOMA OF THE COLON AND RECTUM [J].

ASTLER, VB ;

COLLER, FA .

ANNALS OF SURGERY, 1954, 139 (06) :846-852

[2] CHROMOSOME-17 DELETIONS AND P53 GENE-MUTATIONS IN COLORECTAL CARCINOMAS [J].

BAKER, SJ ;

FEARON, ER ;

NIGRO, JM ;

HAMILTON, SR ;

PREISINGER, AC ;

JESSUP, JM ;

VANTUINEN, P ;

LEDBETTER, DH ;

BARKER, DF ;

NAKAMURA, Y ;

WHITE, R ;

VOGELSTEIN, B .

SCIENCE, 1989, 244 (4901) :217-221

[3] A MULTIVARIATE-ANALYSIS OF CLINICAL AND PATHOLOGICAL VARIABLES IN PROGNOSIS AFTER RESECTION OF LARGE BOWEL-CANCER [J].

CHAPUIS, PH ;

DENT, OF ;

FISHER, R ;

NEWLAND, RC ;

PHEILS, MT ;

SMYTH, E ;

COLQUHOUN, K .

BRITISH JOURNAL OF SURGERY, 1985, 72 (09) :698-702

[4] AMPLIFICATION AND OVER-EXPRESSION OF C-ERBB-2 IN TRANSITIONAL CELL-CARCINOMA OF THE URINARY-BLADDER [J].

COOMBS, LM ;

PIGOTT, DA ;

SWEENEY, E ;

PROCTOR, AJ ;

EYDMANN, ME ;

PARKINSON, C ;

KNOWLES, MA .

BRITISH JOURNAL OF CANCER, 1991, 63 (04) :601-608

[5] NCL-CB11, A NEW MONOCLONAL-ANTIBODY RECOGNIZING THE INTERNAL DOMAIN OF THE C-ERBB-2 ONCOGENE PROTEIN EFFECTIVE FOR USE ON FORMALIN-FIXED, PARAFFIN-EMBEDDED TISSUE [J].

CORBETT, IP ;

HENRY, JA ;

ANGUS, B ;

WATCHORN, CJ ;

WILKINSON, L ;

HENNESSY, C ;

GULLICK, WJ ;

TUZI, NL ;

MAY, FEB ;

WESTLEY, BR ;

HORNE, CHW .

JOURNAL OF PATHOLOGY, 1990, 161 (01) :15-25

[6] TYROSINE KINASE RECEPTOR WITH EXTENSIVE HOMOLOGY TO EGF RECEPTOR SHARES CHROMOSOMAL LOCATION WITH NEU ONCOGENE [J].

COUSSENS, L ;

YANGFENG, TL ;

LIAO, YC ;

CHEN, E ;

GRAY, A ;

MCGRATH, J ;

SEEBURG, PH ;

LIBERMANN, TA ;

SCHLESSINGER, J ;

FRANCKE, U ;

LEVINSON, A ;

ULLRICH, A .

SCIENCE, 1985, 230 (4730) :1132-1139

[7]

COX DR, 1972, J R STAT SOC B, V34, P187

[8]

DEMILIA J, 1989, ONCOGENE, V4, P1233

[9]

DEPOTTER CR, 1989, HISTOPATHOLOGY, V15, P351

[10] The classification of cancer of the rectum [J].

Dukes, CE .

JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1932, 35 (03) :323-332

← 1 2 3 4 →