IMMUNOREGULATORY PROPERTIES OF HEXAPEPTIDE ISOLATED FROM PORCINE BONE-MARROW CELL-CULTURE

被引：21

作者：

MIKHAILOVA, A

FONINA, L

KIRILINA, E

SHANURIN, S

GURYANOV, S

MALAKHOV, A

NESMEYANOV, V

PETROV, R

机构：

[1] Department of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow

来源：

REGULATORY PEPTIDES | 1994年 / 53卷 / 03期

关键词：

BONE MARROW PEPTIDE; MYELOPEPTIDE; ANTIBODY PRODUCTION; IMMUNOCORRECTION; T SUPPRESSOR;

D O I：

10.1016/0167-0115(94)90169-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myelopeptide 1 (MP-1) is hexapeptide originally isolated from porcine bone marrow cell culture. It was synthesized and its immunoregulatory properties were studied. MP-1 caused a 1.5-2-fold dose-dependent increase of antibody production in the culture of mouse immune lymph node cells. It abolished Con A induction of T suppressors in the suspension of mouse spleen cells and counteracted the inhibitory effect of T suppressors on antibody production. The inoculation of MP-1 (1.10(-9) g/mouse) to mice two weeks after their gamma-irradiation (2 Gy) resulted in an increase of antibody production up to 80.2 +/- 15.5% as compared to that in the irradiated control 37.6 +/- 12.0%. Immunofluorescent analysis revealed the specific binding of MP-1 with receptors on the target cells in the suspension of mouse spleen cells. It is supposed that MP-1 participates in the immunoregulatory processes in the living organism.

引用

页码：203 / 209

页数：7

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