INSERTION OF CARBON-MONOXIDE BY USE OF PDII AND PPH3

It has been so far reported that the reaction of carbon monoxide with aryl or vinyl halides in the presence of alcohol or amine smoothly proceeded under atmospheric pressure by use of a catalytic amount of PbII and PPh3 to give esters or amines in good yields. This reaction was extended by us to the synthesis of heterocyclic compounds. The aryl halide having the internal amino, hydroxy and amido groups gave the benzolactams, benzolactones and imido derivatives. A variety of heterocyclic compounds including sendaverine (alkaloid. and anthramycine derivatives (antibiotics. were synthesized by this intramolecular cyclization. © 1979, The Society of Synthetic Organic Chemistry, Japan. All rights reserved.