FOOD-INTAKE AND SELECTION PATTERN OF RATS TREATED WITH DEXFENFLURAMINE, FLUOXETINE AND RU24969

被引:41
作者
LUO, SQ [1 ]
LI, ETS [1 ]
机构
[1] UNIV TORONTO,DEPT NUTR SCI,FITZGERALD BLDG,150 COLL ST,TORONTO M5S 1A8,ONTARIO,CANADA
基金
加拿大自然科学与工程研究理事会;
关键词
Carbohydrate; Dexfenfluramine; Diet selection; Fluoxetine; Protein; RU; 24969; Serotonin;
D O I
10.1016/0361-9230(90)90130-R
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intraperitoneally at 1845 hr, 15 min prior to food access. The drugs exerted their effects mainly during the first hour of feeding (1900-2000 hr). At this time, a selective suppression in intake of the high carbohydrate-low protein diet was the most prominent characteristic of all three serotonergic agonists. This macronutrient specific effect was particularly strong at low dosages (dexfenfluramine, fluoxetine and RU 24969: 0.5 2.0 and 1.0 mg/kg, respectively). With time, as the effect of drugs wore off, diet selection pattern became more variable. The fact that both indirect 5-HT agonists and a direct selective 5-HT receptor agonist share a specific behavioral effect provides additional support for the role of serotonin in the control of macronutrient specific appetites. © 1990.
引用
收藏
页码:729 / 733
页数:5
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