INSULIN-LIKE GROWTH FACTOR-I, GROWTH HORMONE-DEPENDENT INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN AND GROWTH IN CHILDREN WITH CHRONIC-RENAL-FAILURE

被引：19

作者：

HODSON, EM

BROWN, AS

ROY, LP

ROSENBERG, AR

机构：

[1] Department of Paediatrics, Westmead Hospital, Westmead, 2145, New South Wales

[2] Department of Endocrinology, Prince of Wales Hospital, Randwick, 2031, New South Wales

[3] Department of Nephrology, Royal Alexandra Hospital for Children, Camperdown, 2050, New South Wales

[4] Department of Nephrology, Prince of Wales Children's Hospital, Randwick, 2031, New South Wales

来源：

PEDIATRIC NEPHROLOGY | 1992年 / 6卷 / 05期

关键词：

INSULIN-LIKE GROWTH FACTOR-I; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-3; CHRONIC RENAL FAILURE; GROWTH RETARDATION;

D O I：

10.1007/BF00874005

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Insulin-like growth factor-binding protein-3 (IGFBP-3) and insulin-like growth factor-1 (IGF-1) levels were measured by specific radioimmunoassays in children with all degrees of chronic renal failure (CRF). Study group 1 comprised 29 children (10 on dialysis) who had been studied one to four times over 2 years to determine whether IGF-1 and IGFBP-3 levels differed from those in age-matched healthy children and to examine the relationship between these levels and heights. IGF-1 and IGFBP-3 levels did not differ from those in normal children. IGF-1 and IGFBP-3 were significantly correlated, increased with pubertal stage in all children and with age in non-dialysis patients. IGF-1, but not IGFBP-3, correlated with age in dialysis patients. There was no correlation between IGF-1 or IGFBP-3 levels (corrected for age) and height standard deviation score (SDS) in either non-dialysis or dialysis patients. Study group 2 comprised 19 children (7 on dialysis) who were studied prospectively for 1-2 years to examine the relationship between IGF-1 and IGFBP-3 levels, growth rates and nutritional parameters. Mean values of IGF-1 and IGFBP-3 (corrected for age) did not change over 1-year periods, while height SDS fell by -0.38 +/- 0.21 SD/year in dialysis patients and by -0.11 +/- 0.29 SD/year in non-dialysis patients. No significant correlations were found between IGF-1 or IGFBP-3 levels and growth rates or nutritional parameters. Thus growth retardation in children with CRF is not related to circulating levels of IGF-1 or IGFBP-3.

引用

页码：433 / 438

页数：6

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