FNA-CYTODIAGNOSIS OF NON-HODGKINS-LYMPHOMA AND ITS SUBTYPING UNDER WORKING FORMULATION OF 175 CASES

被引:36
作者
DAS, DK
GUPTA, SK
DATTA, BN
SHARMA, SC
机构
[1] Department of Cytology and Gyn. Pathology, Departments of Morbid Anatomy and Pathology, Department of Radiotherapy, Post-Graduate Institute of Medical Education and Research, Chandigarh
[2] Institute of Cytology & Preventive Oncology (ICMR), Maulana Azad Med. College Campus, New Delhi
关键词
HODGKINS DISEASE; FNAC; HIGH GRADE LYMPHOMA; LOW GRADE LYMPHOMA; LARGE CELL LYMPHOMA; SMALL CELL LYMPHOMA;
D O I
10.1002/dc.2840070510
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
One hundred thirty-two cases diagnosed as non-Hodgkin's lymphoma (NHL) by fine-needle aspiration cytology (FNAC) and histology, and 43 cases in which there were minor or major discrepancies between cytology and histology for diagnosis of NHL, were reviewed. The diagnostic accuracy of FNAC for NHL was 86.3% at the initial diagnosis. Following review, all the 132 cases initially diagnosed as NHL by cytology and histology remained so with minor changes in subtypes in a few cases. Of the 43 discrepant cases, 28 turned out to be NHL and 6 as Hodgkin's disease (HD); 3 were anaplastic carcinoma; and in 6 cases the discrepancy still persisted. Diagnostic accuracy of FNA for NHL improved to 98.0% following review. Categorization of histologically diagnosed NHL cases under working formulation showed that 10.4%, 21.5%, and 57.7%, respectively, were low, intermediate, and high-grade lymphomas. The corresponding figures were 16.6%, 18.4%, and 60.1%, respectively, in cytology. The diagnostic accuracy of cytology for subtyping was found to be 67.5%.
引用
收藏
页码:487 / 498
页数:12
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共 33 条
  • [1] Feinberg MR, Bhaskar AG, Bourne P, Differential diagnosis of malignant lymphoma by imprint cytology, Acta Cytol (Baltimore), 24, pp. 16-25, (1980)
  • [2] Lennert K, Malignant lymphomas other than Hodgkin's disease, (1978)
  • [3] Carter TR, Feldman PS, Innes DJ, Frierson HF, Frigy AF, The role of fine needle aspiration cytology in the diagnosis of lymphoma, Acta Cytol (Baltimore), 32, pp. 848-853, (1988)
  • [4] Das DK, Gupta SK, Morphological and functional classification of non Hodgkin's lymphoma: frequency of distribution of subtypes, India J Med Res, 81, pp. 591-601, (1985)
  • [5] Erwin BC, Brynes RK, Chan WC, Et al., Percutaneous needle biopsy in the diagnosis and classification of lymphoma, Cancer, 57, pp. 1074-1078, (1986)
  • [6] Gupta SK, Datta TK, Aikat BK, Lymphnode aspiration biopsy in diagnosis of lymphoma, Indian J Pathol Microbiol, 20, pp. 231-237, (1977)
  • [7] Qizilbash AH, Elevathil LJ, Chen V, Young JEM, Archibald SD, Aspiration biopsy cytology of lymph node in malignant lymphoma, Diagn Cytopathol, 1, pp. 23-27, (1985)
  • [8] Das DK, Gupta SK, Ayagari S, Bambery PK, Datta BN, Datta U, Pleural effusions in nonHodgkin's lymphoma. A cytomorphologic, cytochemical and immunologic study, Act Cytol (Baltimore), 31, pp. 119-124, (1987)
  • [9] Katz RL, Raval P, Manning JT, McLaughlin P, Barlogie B, A morphologic, immunologic and cytometric approach to the classification on nonHodgkin's lymphoma in effusions, Diagn Cytopathol, 3, pp. 91-101, (1987)
  • [10] Spriggs AI, Vanhegan RI, Cytological diagnosis of lymphoma in serous effusions, J Clin Pathol, 34, pp. 1311-1325, (1981)