INTERACTION OF HPV-18 AND NITROSOMETHYLUREA IN THE INDUCTION OF SQUAMOUS-CELL CARCINOMA

被引：58

作者：

GARRETT, LR ^{[1
]}

PEREZREYES, N ^{[1
]}

SMITH, PP ^{[1
]}

MCDOUGALL, JK ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT PATHOL, SEATTLE, WA 98195 USA

来源：

CARCINOGENESIS | 1993年 / 14卷 / 02期

关键词：

D O I：

10.1093/carcin/14.2.329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A strong correlation exists between the presence of specific types of human papillomavirus (HPV) and the development of anogenital cancer, as well as significant epidemiologic evidence suggesting smokers are at increased risk of developing cervical, vulvar and/or anal carcinomas. Primary and human papillomavirus type 18 (HPV-8)-immortalized human keratinocytes were used to address the co-carcinogenic potential of HPV and nitrosomethylurea (NMU) in tumorigenesis. Only cells containing HPV-18 and treated with NMU and the tumor-promoting phorbol ester, TPA, were transformed to a malignant phenotype. An in vitro system is described which initiates studies involving the mechanisms of HPV and chemical carcinogen co-operation in the etiology of squamous cell carcinomas.

引用

页码：329 / 332

页数：4

共 37 条

[1] EFFECT OF AGE ON DOSE-RESPONSE RELATIONSHIP IN CARCINOGENESIS INDUCED BY SINGLE ADMINISTRATION OF N-NITROSOMETHYLUREA IN FEMALE RATS [J].