RANITIDINE PHARMACOKINETICS IN NEWBORN-INFANTS

被引：17

作者：

FONTANA, M

MASSIRONI, E

ROSSI, A

VAGLIA, P

GANCIA, GP

TAGLIABUE, P

PRINCIPI, N

机构：

[1] UNIV MILAN, SCH MED, DEPT PAEDIATR, I-20122 MILAN, ITALY

[2] OSPED SAN CARLO BARROMEO MILANO, DEPT PAEDIATR, MILAN, ITALY

[3] OSPED SAN GERARDO, DIV NEONATAL INTENS CARE, MONZA, ITALY

[4] POLICLIN SAN MATTEO, IRCCS, DIV NEONATAL INTENS CARE, PAVIA, ITALY

来源：

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION | 1993年 / 68卷 / 05期

关键词：

D O I：

10.1136/adc.68.5_Spec_No.602

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Few data are available for ranitidine pharmacokinetics in the first few days of life. Twenty seven newborn infants were treated with intravenous ranitidine because they were vomiting blood, although they had a negative Apt's test. Each infant provided two blood samples at randomly selected times 30-360 minutes after a 2.4 mg/kg intravenous bolus of ranitidine. A single exponential equation for the concentration-time graph was fitted to the mean serum concentrations at,different times. From this model the following mean (SD) measurements were derived: elimination half life, 207.1 (19.1) minutes; total volume of distribution, 1.52 (0.91) l/kg; and total plasma clearance, 5.02 (0.46) ml/kg/min. Assuming that these measurements do not change with different administered doses, regimens can be derived to assist in planning ranitidine treatment in newborn infants.

引用

页码：602 / 603

页数：2

共 13 条

[1] NEW LOOK AT STATISTICAL-MODEL IDENTIFICATION [J].