CIRCADIAN VARIATIONS OF PROSTAGLANDINS D-2, E(2), AND F2-ALPHA IN THE CEREBROSPINAL-FLUID OF ANESTHETIZED RATS

被引：22

作者：

PANDEY, HP ^{[1
]}

RAM, A ^{[1
]}

MATSUMURA, H ^{[1
]}

SATOH, S ^{[1
]}

HAYAISHI, O ^{[1
]}

机构：

[1] OSAKA BIOSCI INST,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 213卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circadian variations in the levels of prostaglandins (PGs) D-2, E(2), and F-2 alpha were studied in the cerebrospinal fluid (CSF) of rats. We collected CSF samples from the cisterna magna of anesthetized rats at different clock-hours (1000, 1400, 1800, 2200, 0200, and 0600 hr), and measured the concentrations of the three PGs. PGD(2), which appeared to be the most abundant among the three, showed a circadian variation; and the mean of the day-time levels (145 pg/ml) was significantly higher than that of the nighttime ones (111 pg/ml). Day/night variations were also noticed with the levels of PGE(2) and PGF(2 alpha); however, these levels remained 3-4 times lower than those of PGD(2). The general day/night variation seen in the CSF concentration of PGD(2) conforms well with the postulated role of PGD(2) as an endogenous sleep-promoting factor acting on a certain brain surface area defined as its site of action. (C) 1995 Academic Press, Inc.

引用

页码：625 / 629

页数：5

共 23 条

[1] CEREBROSPINAL-FLUID EICOSANOID LEVELS - ENDOGENOUS PGD2 AND LTC4 SYNTHESIS BY ANTIGEN-PRESENTING CELLS THAT MIGRATE TO THE CENTRAL-NERVOUS-SYSTEM [J].