ANTI-PRES2 ANTIBODY-ASSAY FOR EVALUATING IMMUNE-RESPONSES AMONG RECIPIENTS OF RECOMBINANT HEPATITIS-B PRES2+S VACCINE

被引：4

作者：

HURNI, WM

ROEHM, RR

MILLER, WJ

机构：

[1] Virus and Cell Biology Research, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania

来源：

JOURNAL OF MEDICAL VIROLOGY | 1990年 / 30卷 / 02期

关键词：

clinical trial; competitiveria; HBV; MAb;

D O I：

10.1002/jmv.1890300213

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A competitive radioimmunoassay was developed for measuring hepatitis B virus (HBV) anti‐PreS2 antibody. The assay has been demonstrated to be highly specific for anti‐PreS2 antibody and not subject to interference by other antibodies to HBV‐specific antigens. This assay was used to evaluate anti‐PreS2 antibody responses in a hepatitis B PreS2+S vaccine human clinical trial in healthy adults. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

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页码：146 / 150

页数：5

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