EFFECT OF DRUGS ON CRYSTAL ADHESION TO INJURED UROTHELIUM

被引：11

作者：

PANTAZOPOULOS, D

KARAGIANNAKOS, P

SOFRAS, F

KOSTAKOPOULOS, A

DELIVELIOTIS, C

DIMOPOULOS, C

机构：

[1] LAIKON GEN HOSP,DEPT SURG RES,ATHENS,GREECE

[2] LAIKON GEN HOSP,DEPT EXPTL SURG,ATHENS,GREECE

[3] LAIKON GEN HOSP,DEPT UROL,ATHENS,GREECE

[4] UNIV ATHENS,ATHENS,GREECE

来源：

UROLOGY | 1990年 / 36卷 / 03期

关键词：

D O I：

10.1016/0090-4295(90)80268-R

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The normal urothelium is covered by a glycosaminoglycan (GAG) layer which actsas a barrier to the adhesion of crystals. Destruction of the GAG layer increases the number of adhered crystals, and it is therefore assumed that it promotes crystal growth and stone formation. Intravesical instillation of pentosanpolysulfate, an exogenous glycosaminoglycan, after destruction of this layer reduces the adhesion of crystals to the urothelium. Intramuscular administration of carbenoxolone sodium following the experimental destruction of the GAG layer increases the rate of healing of the layer and reduces the number of adhered crystals. © 1990.

引用

页码：255 / 259

页数：5

共 17 条

[1] POVIDONE-IODINE BLADDER INJURY IN RATS AND PROTECTION WITH HEPARIN [J].