FUSION OF EMBRYONAL CARCINOMA-CELLS TO FIBROBLAST CELLS, CYTOPLASTS, AND KARYOPLASTS - DEVELOPMENTAL PROPERTIES OF VIABLE FUSION PRODUCTS

被引：34

作者：

MCBURNEY, MW

STRUTT, B

机构：

[1] Department of Biology, University of Ottawa, Ottawa

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 124卷 / 01期

关键词：

D O I：

10.1016/0014-4827(79)90267-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Developmentally pluripotent embryonal carcinoma cells isolated from mouse teratocarcinomas were fused to whole cells, to cytoplasts and to karyoplasts of 3T3 fibroblasts. The cybrids (cell .times. cytoplast fusion product) retained the developmental potency of the embryonal carcinoma cell parent. The karyobrids (cell .times. karyoplast fusion product) and the hybrids resembled the fibroblast parent cell and were incapable of differentiation. These experiments failed to reveal the presence of cytoplasmic regulators of nuclear gene expression.

引用

页码：171 / 180

页数：10

共 15 条

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