MECHANISM FOR ULTRASONICALLY ENHANCED TRANSMEMBRANE SOLUTE PERMEATION

被引：8

作者：

JULIAN, TN ^{[1
]}

ZENTNER, GM ^{[1
]}

机构：

[1] UNIV CONNECTICUT,SCH PHARM,STORRS,CT 06268

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 12卷 / 01期

关键词：

transmembrane permeation; ultrasonic enhancement;

D O I：

10.1016/0168-3659(90)90185-V

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The transmembrane permeation of benzoic acid in polydimethylsiloxane and hydrocortisone in cellulose was characterized under conditions of ultrasonic (20 kHz) perturbation. In all cases the measured partition coefficients were independent of both temperature and ultrasonic energy input. Diffusion coefficients were directly proportional to the applied ultrasonic energy (0-45 W) when the donor reservoir was sonicated; a decrease in the activation energy for diffusion of approximately 300 cal/mol was observed for both solute/membrane systems at 33 W ultrasonic energy input. Diffusion coefficients measured under conditions of receptor reservoir sonication and no ultrasonic perturbation were similar. The results were consistent with a mechanism in which the solution-membrane interfacial transfer rate was increased by ultrasonic energy. © 1990.

引用

页码：77 / 85

页数：9

共 33 条

[1]

Skauen, Zentner, Int. J. Pharm., 20, (1984)

[2]

Kost, Leong, Langer, Makromol Symp, Makromolekulare Chemie. Macromolecular Symposia, 19, (1988)

[3]

Kost, Leong, Langer, Polym. Sci. Technol., 34, (1986)

[4]

Miyazaki, Yokouchi, Takada, J. Pharm. Pharmacol., 40, 10, (1988)

[5]

Julian, Zentner, J. Pharm. Pharmacol., 38, (1986)

[6]

Crank, Park, Diffusion in Polymers, (1968)

[7]

Barrer, J. Phys. Chem., 61, (1957)

[8]

Barrer, Skirrow, Transport and equilibrium phenomena in gas–elastomer systems. I. Kinetic phenomena, Journal of Polymer Science, 3, (1948)

[9]

Barrer, Chio, J. Polym. Sci., 10, (1965)

[10]

Barrer, Trans. Faraday Soc., 38, (1942)

← 1 2 3 4 →