CHIRAL SYNTHESIS OF POLYKETIDE DERIVED NATURAL-PRODUCTS .27. STEREOSELECTIVE SYNTHESIS OF ERYTHRONOLIDE-A VIA AN EXTREMELY EFFICIENT MACROLACTONIZATION BY THE MODIFIED YAMAGUCHI METHOD

被引：147

作者：

HIKOTA, M ^{[1
]}

TONE, H ^{[1
]}

HORITA, K ^{[1
]}

YONEMITSU, O ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 01期

关键词：

D O I：

10.1021/jo00288a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: The seco-acid derivative 7, which has the 9,11-and 3,5-diols protected as the mesityl- and 3,4-dimeth-oxypheny- (DMP) acetals, respectively, was stereoselectively synthesized from D-glucose and converted to Yam-aguchi's mixed anhydride, which was treated with a high concentration of DMAP at room temperature to rapidly give the 14-membered lactone in 98% yield. Removal of the protecting groups gave 9-dihydroerythronolide A. © 1990, American Chemical Society. All rights reserved.

引用

页码：7 / 9

页数：3

共 17 条

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