HEPATITIS-B VIRUS MUTANTS WITH PRECORE-REGION DEFECTS IN 2 BABIES WITH FULMINANT-HEPATITIS AND THEIR MOTHERS POSITIVE FOR ANTIBODY TO HEPATITIS-B-E ANTIGEN

被引：96

作者：

TERAZAWA, S

KOJIMA, M

YAMANAKA, T

YOTSUMOTO, S

OKAMOTO, H

TSUDA, F

MIYAKAWA, Y

MAYUMI, M

机构：

[1] JICHI MED SCH,DIV IMMUNOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

[2] KITASATO INST,IMMUNOL SECT,TOKYO 108,JAPAN

[3] MITA INST,TOKYO 108,JAPAN

[4] PREFECTURAL GERO HOSP,DEPT PEDIAT,GIFU 50922,JAPAN

[5] SAPPORO MED COLL,DEPT PEDIAT,SAPPORO,HOKKAIDO 060,JAPAN

[6] KOJIMA CLIN,GIFU 500,JAPAN

来源：

PEDIATRIC RESEARCH | 1991年 / 29卷 / 01期

关键词：

D O I：

10.1203/00006450-199101000-00002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Clones of hepatitis B virus (HBV) DNA were propagated from sera of two babies who developed neonatal fulminant hepatitis B, as well as from sera of their mothers who carried HBV with antibody to hepatitis B e antigen, and the precore-region sequences were determined. A point mutation from guanine to adenine, converting codon 28 for tryptophan (TGG) to a stop codon (TAG), was detected in 18 of 20 HBV DNA clones from mother and all 31 clones from baby in one family, and invariably in 55 clones from mother and three clones from baby in the other family. These results indicate that HBV mutants defective in the precore region in some carrier mothers with antibody to hepatitis B e antigen may transmit fulminant hepatitis B to their babies.

引用

页码：5 / 9

页数：5

共 35 条

[1] CHRONIC ACTIVE HEPATITIS WITH HEPATITIS-B VIRUS-DNA AND ANTIBODY AGAINST E-ANTIGEN IN THE SERUM - DISTURBED SYNTHESIS AND SECRETION OF E-ANTIGEN FROM HEPATOCYTES DUE TO A POINT MUTATION IN THE PRECORE REGION [J].