SELECTIVE INCREASE OF AMPA BINDING TO THE AMPA QUISQUALATE RECEPTOR IN THE HIPPOCAMPUS IN RESPONSE TO ACUTE STRESS

被引：53

作者：

TOCCO, G

SHORS, TJ

BAUDRY, M

THOMPSON, RF

机构：

[1] Neurosciences Program, University of Southern California, Los Angeles

来源：

BRAIN RESEARCH | 1991年 / 559卷 / 01期

关键词：

STRESS; GLUTAMATE RECEPTOR; ALPHA-AMINO-3-METHYLISOXAZOLE-4-PROPIONIC ACID; HIPPOCAMPUS; QUISQUALATE; NORMAL-METHYL-D-ASPARTATE;

D O I：

10.1016/0006-8993(91)90302-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The binding properties of ligands specific for two subclasses of glutamate receptors were studied by quantitative autoradiography after one hour of acute immobilization/shock stress. [H-3]N-(1-(2-thienyl)cyclohexy)-3,4-piperidine (TCP) and [H-3]alpha-amino-3-methylisoxazole-4-propionic acid (AMPA) were used to visualize the N-methyl-D-aspartate receptor and the AMPA/quisqualate receptor types, respectively. While no change was observed in the binding properties of the [H-3]TCP, [H-3]AMPA binding was significantly increased in several areas of the hippocampus of acutely stressed rats relative to naive controls.

引用

页码：168 / 171

页数：4

共 37 条

[1] EFFECTS OF STRESS ON [H-3] CYCLOHEXYLADENOSINE BINDING TO RAT-BRAIN MEMBRANES [J].