SCH-42137, A NOVEL ANTIFUNGAL ANTIBIOTIC FROM AN ACTINOPLANES SP - FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

被引：19

作者：

COOPER, R

TRUUMEES, I

GUNNARSSON, I

LOEBENBERG, D

HORAN, A

MARQUEZ, J

PATEL, M

GULLO, V

PUAR, M

DAS, P

MITTELMAN, S

机构：

[1] SCHERING PLOUGH CORP,RES,MICROBIAL PROD,BLOOMFIELD,NJ 07003

[2] SCHERING PLOUGH CORP,RES,MOLEC SPECT,BLOOMFIELD,NJ 07003

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 04期

关键词：

D O I：

10.7164/antibiotics.45.444

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel polycyclic xanthone, Sch 42137, related to the albofungin family of compounds was isolated from culture broth. Its structure was determined by detailed spectroscopic studies and comparison of circular dichroic studies to related compounds albofungin and simaomicin. Sch 42137 exhibited MIC values < 0.125-mu-g ml against yeasts and dermatophytes. Details are presented herein.

引用

页码：444 / 453

页数：10

共 15 条

[1] Cooks R. G., 1973, METASTABLE IONS
[2] METABOLITES OF MICROORGANISMS .162. CRYSTAL AND MOLECULAR-STRUCTURE OF LYSOLIPIN-I
DOBLER, M
KELLERSCHIERLEIN, W
[J]. HELVETICA CHIMICA ACTA, 1977, 60 (01) : 178 - 185
[3] GUREVICH AI, 1972, ANTIBIOT MED BIOTEK, V17, P771
[4] GUREVICH AI, 1974, TETRAHEDRON LETT, P2801
[5] Harada N., 1983, CIRCULAR DICHROIC SP
[6] ACTINOPLANONES-A AND ACTINOPLANONES-B, NEW CYTO-TOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP
KOBAYASHI, K
NISHINO, C
OHYA, J
SATO, S
MIKAWA, T
SHIOBARA, Y
KODAMA, M
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (04) : 502 - 511
[7] ACTINOPLANONE-C, ACTINOPLANONE-D, ACTINOPLANONE-E, ACTINOPLANONE-F AND ACTINOPLANONE-G, NEW CYTO-TOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP
KOBAYASHI, K
NISHINO, C
OHYA, J
SATO, S
MIKAWA, T
SHIOBARA, Y
KODAMA, M
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (06) : 741 - 750
[8] LECHEVALIER MP, 1968, J LAB CLIN MED, V71, P934
[9] Lee T. M., 1986, 26TH PROGR ABSTR INT, P136
[10] STRUCTURE DETERMINATION OF SIMAOMICINS ALPHA AND BETA, EXTREMELY POTENT, NOVEL ANTICOCCIDAL AGENTS PRODUCED BY ACTINOMADURA
LEE, TWM
CARTER, GT
BORDERS, DB
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (22) : 1771 - 1772

← 1 2 →