DBCAMP EFFECT ON THE EXPRESSION OF GFAP AND OF ITS ENCODING MESSENGER-RNA IN ASTROGLIAL PRIMARY CULTURES

被引：57

作者：

LEPRINCE, G ^{[1
]}

FAGES, C ^{[1
]}

ROLLAND, B ^{[1
]}

NUNEZ, J ^{[1
]}

TARDY, M ^{[1
]}

机构：

[1] HOP HENRI MONDOR,INSERM,U282,F-94010 CRETEIL,FRANCE

来源：

GLIA | 1991年 / 4卷 / 03期

关键词：

ASTROCYTE;

D O I：

10.1002/glia.440040310

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Short term and chronic dBcAMP effects on the expression of glial fibrillary acidic protein (GFAP) in astroglial primary cultures are investigated. Short (48 h) and long (more than 7 days) treatments with the cAMP derivative induce both cell shape changes and an increase in GFAP immunolabelling. Such effects are only associated with an increase in GFAP and in GFAP-mRNA levels in the long term treatment. These results suggest that the short term effect of dBcAMP induces post-translational modifications of the protein whereas the long term effect is associated with an increase in GFAP mRNA transcription and/or stability.

引用

页码：322 / 326

页数：5

共 27 条

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