NEW METHODS FOR THE CONTROL OF MULTIPLE STEREOCENTERS

被引：35

作者：

LAUTENS, M

机构：

[1] Department of Chemistry, University of Toronto, Toronto, Ontario

来源：

PURE AND APPLIED CHEMISTRY | 1992年 / 64卷 / 12期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1351/pac199264121873

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactions which assemble multiple stereocenters in a highly convergent manner provide new avenues for the synthesis of complex natural products. Oxabicyclic compounds have been shown to be useful precursors to highly functionalized cyclic and acyclic compounds following reaction with a variety of nucleophiles including carbon, silicon and hydride. The regio-, stereo-, and enantioselectivity of the ring opening has been investigated. Syntheses of fragments of the natural products rifamycin and ionomycin illustrate the utility of this approach.

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页码：1873 / 1882

页数：10

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